Many theories exist regarding the origin of cancer, namely the metabolic theory (Seyfried & Chinopoulos, 2021), the somatic mutation theory (SMT) (Hanahan & Weinberg, 2000), the cancer stem cell theory (Capp, 2019), and the tissue organization theory (Soto & Sonnenschein, 2011). In a recently published study, a new concept was introduced the mitochondrial-stem cell connection (MSCC) (Martinez, et al., 2024). This concept combines the cancer stem cell theory and the metabolic theory. The MSCC theory suggests that cancer arises from impaired oxidative phosphorylation (OxPhos) in one or more stem cells, potentially leading to the formation of cancer stem cells (CSCs) and, consequently, tumorigenesis.